Sconmet: Spraul Consulting in Nuclear Magnetic Resonance based Metabolomics
Why is metabolomics important?
The non-invasive nature of metabolomics and its close link to the phenotype enable an efficient tool kit for the pharmaceutical, preventive healthcare, agricultural and food industries as well as medical research and future diagnostics. Biomarker discovery and drug safety screening are two examples where metabolomics has already enabled performing factual decisions. In contrary to Genomics, Metabolomics is highly dynamic and sensitive to even smalles changes in the overall composition. With the rapidly growing knowledge on personalised metabolomics, we will be able to longitudinally track the trends of our own metabolome for personalised drugs, personalized nutrition and more efficient treatment strategies. Personalized treatment is likely to be more effective than current medical population-based procedures.
Why is NMR important in Metabolomics
- One of the two most efficient tools for complex mixture analysis
- Completely standardized and fully automatic
- Highly reproducible
- non destructive
- rapid change of matrices (e.g. plasma to urine)
- Completely transferable between identical instruments
- Straightforward sample preparation
- Highest dynamic range without the need to divert high concentration peaks as in MS
- Can analyze a multitude of parameters from small molecules to lipoproteins/proteins with one sample preparation and measurement
- Lipoprotein subclass in plasma/serum analysis within minutes
- allows to combine data from multiple instruments of the same type as for example needed in large epidemiological studies
Metabolomics NMR Services 